Experimental and Computational Modelling of Human Airways as a Tool for Efficient Inhalation Therapy, invited lecture at XV. International conference BIOIMPLANTOLOGY and regenerative medicine 2024

lecture

en

The lecture explores how experimental and computational fluid and particle mechanics (CFPD) techniques can revolutionize the efficiency of inhaled medication delivery. We will delve into the fundamental mechanisms by which inhaled particles deposit within the respiratory system (inertial impaction, interception, sedimentation, diffusion, and electrostatic precipitation). Subsequently, the Brno lung model, a simplified representation of human airways, will be introduced. Crucially, this model bridges the gap between cascade impactors used during the development of inhaled medications and real human airways. The model exists in both physical and digital forms, sharing identical geometry. This allows for direct validation of computational results against experimental measurements and helps us understand details not traceable in in vivo studies. Finally, the lecture will outline the future of inhaled medicine research: Simulating lung diseases: Modeling can predict how diseases impact drug deposition patterns. Localized drug delivery and the effect of particle shape: Targeting specific areas for higher treatment effectiveness and exploring the role of inhaled fibers. Realistic simulations: Modeling airway wall movement, mucus, particle growth, and electrostatic forces is key to accurate simulations. This approach has the potential to optimize inhalation therapy, leading to improved patient outcomes and could ultimately transform how we approach respiratory diseases.

The lecture explores how experimental and computational fluid and particle mechanics (CFPD) techniques can revolutionize the efficiency of inhaled medication delivery. We will delve into the fundamental mechanisms by which inhaled particles deposit within the respiratory system (inertial impaction, interception, sedimentation, diffusion, and electrostatic precipitation). Subsequently, the Brno lung model, a simplified representation of human airways, will be introduced. Crucially, this model bridges the gap between cascade impactors used during the development of inhaled medications and real human airways. The model exists in both physical and digital forms, sharing identical geometry. This allows for direct validation of computational results against experimental measurements and helps us understand details not traceable in in vivo studies. Finally, the lecture will outline the future of inhaled medicine research: Simulating lung diseases: Modeling can predict how diseases impact drug deposition patterns. Localized drug delivery and the effect of particle shape: Targeting specific areas for higher treatment effectiveness and exploring the role of inhaled fibers. Realistic simulations: Modeling airway wall movement, mucus, particle growth, and electrostatic forces is key to accurate simulations. This approach has the potential to optimize inhalation therapy, leading to improved patient outcomes and could ultimately transform how we approach respiratory diseases.

human airways, fibers, fibres, modelling, inhalation

25.04.2024

České vysoké učení technické v Praze

Lednice

26–26

1