Regionální depozice inhalovaných částic v lidských dýchacích cestách

The regional deposition of inhaled porous particles in the human respiratory airways

abstrakt

en

The copper sulphate particles were dispersed using Small–scale powder disperser 3433, TSI and introduced into the segmented lung cast. The cast consists of respiratory airways from oral cavity to seventh generation of branching. The deposition experiments were performed for stationary inspiration. The cast was disassembled after the experiment and every segment was rinsed with isopropanol. The resulted solutions were analysed using atomic absorption spectroscopy in UV/VIS area. Concentrations of copper sulphate in different segments were acquired and data about regional deposition in respiratory airways were calculated.

Částice ze síranu měďnatého byly rozptýleny Small–scale powder disperserem 3433, TSI, a přivedeny do segmentovaného modelu plic. Model obsahuje dýchací cesty od ústní dutiny do sedmé generace větvení. Depoziční experimenty byly provedeny pro stacionární nádech. Poté byl model rozebrán na segmenty a ty byly vymyty isopropanolem. Výsledný roztok byl analyzován Uv/VIS spektrometrií. Na základě zjištěných koncentrací síranu měďnatého byla vypočtena regionální depozice částic v dýchacích cestách.

The copper sulphate particles were dispersed using Small–scale powder disperser 3433, TSI and introduced into the segmented lung cast. The cast consists of respiratory airways from oral cavity to seventh generation of branching. The deposition experiments were performed for stationary inspiration. The cast was disassembled after the experiment and every segment was rinsed with isopropanol. The resulted solutions were analysed using atomic absorption spectroscopy in UV/VIS area. Concentrations of copper sulphate in different segments were acquired and data about regional deposition in respiratory airways were calculated.

Particles, aerosol, regional deposition, airways

06.09.2015

Italian Aerosol Society

Milano, Italy

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