Deposition of rigid glass fibres inside a replica of female airways

článek ve sborníku mimo WoS a Scopus

en

Inhaled fibrous microparticles can pose serious health risks, which have led to significant attention in the last decades. Fibres, particularly the smaller ones, can penetrate deeply into the lungs and reach the alveoli. Their elongated shape causes this. Usual inhalable spherical drugs in the size range of 5 – 10 µm have difficulty reaching the deeper regions of the lung. Thus, the fibrous shape may provide a solution for delivery in these regions, but the mechanics of inhaled fibre flow are more complex compared to spherical particles. Therefore, it is important to understand how specific parameters (e.g. breathing flowrate, dimensions of fibres) influence the flow and deposition of fibrous aerosols in the human airways.

Inhaled fibrous microparticles can pose serious health risks, which have led to significant attention in the last decades. Fibres, particularly the smaller ones, can penetrate deeply into the lungs and reach the alveoli. Their elongated shape causes this. Usual inhalable spherical drugs in the size range of 5 – 10 µm have difficulty reaching the deeper regions of the lung. Thus, the fibrous shape may provide a solution for delivery in these regions, but the mechanics of inhaled fibre flow are more complex compared to spherical particles. Therefore, it is important to understand how specific parameters (e.g. breathing flowrate, dimensions of fibres) influence the flow and deposition of fibrous aerosols in the human airways.

fibres;fibers;glass;female airways;inhalation

11.11.2024

Czech Aerosol Society

Milovy - Sněžné

978-80-908653-2-7

PROCEEDINGS of the 23rd Annual Conference of the Czech Aerosol Society OVZDUŠÍ V ČASe

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